منابع مشابه
Ecce 2009
The metaphysical assumptions of cognitive science are explored with the goal to develop a problem-centered science relevant to the design and engineering of effective products and technologies. Radical Empiricism is suggested as an ontological foundation for pursuing this goal. This ontology poses a single reality where mind and matter come together to shape experience. Peirce’s triadic semioti...
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In vitro–in vivo correlation (IVIVC) of intrinsic clearance in preclinical species of rat and dog was established using the hepatocyte relay method to support high-confidence prediction of human pharmacokinetics for low-clearance compounds. Good IVIVC of intrinsic clearance was observed for most of the compounds, with predicted values within 2-fold of the observed values. The exceptions involve...
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Cerlapirdine (SAM-531, PF-05212365) is a selective, potent, full antagonist of the 5-hydroxytryptamine 6 (5-HT6) receptor. Cerlapirdine and other 5-HT6 receptor antagonists have been in clinical development for the symptomatic treatment of Alzheimer’s disease. A human absorption, distribution, metabolism, and excretion study was conducted to gain further understanding of the metabolism and disp...
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Tissue homeostasis is maintained by adult stem cells, which selfrenewand give rise to differentiating cells. The generation of daughter cells with different fates is mediated by signalling molecules coming from an external niche or being asymmetrically dispatched between the two daughters upon stem cell mitosis. In the adult Drosophila midgut, the intestinal stem cell (ISC) divides to generate ...
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ژورنال
عنوان ژورنال: IEEE Power Electronics Magazine
سال: 2023
ISSN: ['2329-9215', '2329-9207']
DOI: https://doi.org/10.1109/mpel.2023.3279170